Page 19 - Delaware Medical Journal - March/April 2021
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 COVER STORY
    of the processes underlying cancer development. This major effort has and will continue to bring cutting-edge cancer research to our patients so that they do not have to leave Delaware for their care.
Scientists and clinicians working together under one roof as described in this summary will, over the course of         process toward application in humans and help us to continue to decrease cancer incidence and mortality rates
in Delaware. This effort will indeed “Extend the Boundaries and Accelerate the Cure.” It is a legacy for the next generation of Delawareans that these scientists and clinicians will leave.
REFERENCES
1. Siegel, S.,Miller,K., Fuchs, H., Jemal,A. Cancer Statistics, 2021;71;7-33.
2. Grubbs S, Polite B, Carney J, Bowser W, Rogers J, Katurakes N, Hess P, Paskett E. Eliminating racial disparities in colorectal cancer in the real world: it took a village. J Clin Oncol, 31(16): 1928-1930, 2013.
3. Petrelli N, Grubbs S, Price K. Clinical trial investigator status: you need to earn it. J Clin Oncol, 26(15): 2440-2441, 2008.
4. O’Donoghue C, Eklund M, Ozanne EM, Esserman LJ. Aggregate cost of mammography screening in the United States: comparison of current practice and advocated guidelines. Ann Intern Med, 160(3): 145, 2014 Feb 4. doi: 10.7326/M13-1217
5. Le MT, Mothersill CE, Seymour CB, and McNeill FE. Is the false-positive rate in mammography in North America too high? Br J Radiol. 2016 Sep;89(1065):20160045. doi: 10.1259/bjr.20160045
6. Cancer Incidence and Mortality in Delaware, 2009-2013. Delaware Health and Social Services Division of Public Health, 2017.
7. Baker S. Combined associations of genetic and environmental risk factors: implications for prevention of breast cancer.
J Natl Cancer Inst, 107(6), 2015. djv127, https://doi.org/ 10.1093/jnci/djv127
■ ERIC KMIEC, PHD, is the Senior Research Scientist at the Cawley Center for Translational Cancer Research and the Director of the Gene Editing Institute of the Helen F. Graham Cancer Center and Research Institute at ChristianaCare in Newark.
■ BRUCE BOMAN, MD, PHD, is a Senior Research Scientist at the Cawley Center for Translational Cancer Research and the Director of the Colorectal Cancer Translational Research Program at the Helen F. Graham Cancer Center and Research Institute at ChristianaCare in Newark.
CONTRIBUTORS
■ NICHOLAS PETRELLI, MD, is the Bank of America endowed Medical Director of the Helen F. Graham Cancer Center and Research Institute at ChristianaCare in Newark. He is a nationally recognized expert on colorectal cancer.
■ JENNIFER SIMS-MOURTADA, PHD, is a Senior Research Scientist at the Cawley Center for Translational Cancer Research and the Director of Translational Breast Cancer Research Program at the Helen F. Graham Cancer Center and Research Institute at ChristianaCare in Newark.
ACKNOWLEDGMENTS
  The clinical collaborators for translational cancer research: Charles Mulligan, MD; Brian Nam, MD;
Adam Raben, MD; Neil Hockstein, MD; Firas Mourtada, PhD; Mark Borowsky, MD; Mark Cadungog, MD; Stephanie Jean, MD; Jamal Khatri, MD; Diana Dickson-Witmer, MD; Greg Masters, MD; Michael Guarino, MD; David Biggs, MD; Scott Hall, MD; Ramya Varadarajan, MD; Jason Palopoli, MD; Joseph Bennett,
MD; Greg Tiesi, MD; Raafat Abdel-Misih, MD; Nora Katurakes, MSN, RN, OCN; Zohra Ali-Khan Catts, MS, LCGC; Kandie Dempsey, DBA, MS, RN, OCN; Lynn Opdenaker, PhD, Cawley Center for Translational Cancer Research Manager; Patricia Swanson, RN, Project Manager, Translational Cancer Research, HFGCCRI.
  8. Sims-Mourtada J, Ali-Khan Catts Z, Swanson P, Katurakes N. Engaging African Americans in breast cancer prevention strategies: a partnership between a community cancer center and the African American community in Delaware. Cancer Studies Mol Med, 2019. 5(i):e1-e3 doi 10.17140/CSMMOj-5-e007.
9. Boman BM, Huang E. Human colon cancer stem cells: a new paradigm in gastrointestinal oncology. J Clin Oncol, 26:2828- 38, 2008.
10. Boman BM, Wicha MS. Cancer stem cells: a step toward the cure. J Clin Oncol, 26:2795-9, 2008.
11. Modarai SR, Gupta A, Opdenaker LM, Kowash R, Masters G, Viswanathan V, Zhang T, Fields JZ, Boman BM. The anti-cancer effect of retinoic acid signaling in CRC occurs via decreased growth of ALDH+ colon cancer stem cells and increased differentiation of stem cells. OncoTarget 9:34658-69, 2018.
12. Kmiec EB. CRISPR-directed gene editing in a community cancer center. Oncology Issues, 34(1): 31-37, 2019.
13. Bialk P, Wang Y, Banas K, Kmiec E. Functional gene knockout of NRF2 increases chemosensitivity of human lung cancer A549 cells in vitro and in xenograft mouse model. Molecular Therapy Oncolytics, 11: 75-89, 2018.
14. Petrelli N. Cancer care in Delaware: a model for America. Delaware Med J, 89(11): 346, 2017.
15. Goldberg P. Christiana Care and Wistar seek NCI recognition of their unique alliance. The Cancer Letter, cancerletter.com, July 2019.
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