Page 26 - Delaware Medical Journal - March 2018

CONTRIBUTING AUTHORS
■ SHELBY CATLETT, MD is an Emergency Medicine Resident at Christiana Care Health System in Newark, Delaware.
■ CHRISTIAN COLETTI, MD, MHCDS is an Emergency/Internal Medicine Physician and Medical Director of the Wilmington Emergency Department.
REFERENCES
1. Defronzo RA. Pharmacologic Therapy for Type 2 Diabetes Mellitus. 2017:281-303.
2. Prospective UK, Study D. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes. 1998;352(Ukpds 34).
3. Bodmer, M., Meier, C., Jick, S., Meier, C.R., Krahenbuhl S. Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia. Diabetes Care. 2008;31(11):p2086-91. doi:10.2337/dc08-1171.
4. Defronzo R, Fleming GA, Chen K, Bicsak TA. Metformin-associated lactic acidosis: Current perspectives on causes and risk. Metabolism. 2016;65(2):20-29. doi:10.1016/j.metabol.2015.10.014.
5. Richy FF, Sabido-Espin M, Guedes S, Corvino FA, Gottwald-Hostalek U. Incidence of lactic acidosis in patients with type 2 diabetes with and without renal impairment treated with metformin: A retrospective cohort study. Diabetes Care. 2014;37(8):2291-2295. doi:10.2337/dc14-0464.
6. Salpeter S, Greyber E, Pasternak G, Salpeter E. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus (Review). Cochrane Database Syst Rev. 2002;(4):CD002967. doi:10.1002/14651858.CD002967.pub4.
7. Kraut, J, Madias NE. Lactic acidosis. N Engl J Med. 2014;371(24):2309-2319.
8. FDA U. FDA Drug Safety Communication: FDA revises warnings regarding use of the diabetes medicine metformin in certain patients with
reduced kidney function. 2016:1-3. http://www.fda.gov/downloads/Drugs/DrugSafety/UCM494140.pdf.
9. Silvestre J, Carvalho S, Mendes V, et al. Metformin-induced lactic acidosis: a case series. J Med Case Rep. 2007;1(1):126. doi:10.1186/1752- 1947-1-126.
10. Weisberg LS. Attending Rounds Lactic Acidosis in a Patient with Type 2 Diabetes Mellitus. Clin J Am Soc Nephrol. 2015;10(8):1476-1483. doi:10.2215/CJN.10871014.
Physicians bring economic health to our communities.
The 2018 AMA Economic Impact Study demonstrates how physicians contribute mightily to the health of Delaware’s economy.
25,791
JOBS
$4.8 billion
IN ECONOMIC ACTIVITY
$164.6 billion
IN STATE & LOCAL TAX REVENUES
$2.4 billion
IN WAGES & BENEFITS
Physicians’ impact is felt far beyond the exam room, reaching through local communities, producing a network of jobs and spurring local investment.
Learn more at PhysiciansEconomicImpact.org
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